Ultradeep sequencing of Hi-C data from mouse cells in different developmental stages can address outstanding questions about 3D chromatin function.
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References
Bonev, B. et al. Multiscale 3D genome rewiring during mouse neural development. Cell 171, 557–572.e24 (2017).10.1016/j.cell.2017.09.043
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Rusk, N. Multiscale 3D view of the genome. Nat Methods 14, 1126–1127 (2017). https://doi.org/10.1038/nmeth.4529
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DOI: https://doi.org/10.1038/nmeth.4529