Useful new methods are being introduced to experimentally determine the genome-wide consequences of Cas9-based editing.
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References
Tsai, S.Q. et al. Nat. Methods 14, 607–614 (2017).
Cameron, P. et al. Nat. Methods 14, 600–606 (2017).
Carroll, D. Annu. Rev. Biochem. 83, 409–439 (2014).
Tebas, P. et al. N. Engl. J. Med. 370, 901–910 (2014).
Qasim, W. et al. Sci. Transl. Med. 9, eaaj2013 (2017).
Bibikova, M., Golic, M., Golic, K.G. & Carroll, D. Genetics 161, 1169–1175 (2002).
Tsai, S.Q. et al. Nat. Biotechnol. 33, 187–197 (2015).
Kim, D. et al. Nat. Methods 12, 237–243 (2015).
Knight, S.C. et al. Science 350, 823–826 (2015).
Urnov, F. Nature 529, 468–469 (2016).
Shalem, O., Sanjana, N.E. & Zhang, F. Nat. Rev. Genet. 16, 299–311 (2015).
Urnov, F.D. et al. Nature 435, 646–651 (2005).
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Urnov, F. Cas9 in action: no more known unknowns?. Nat Methods 14, 563–564 (2017). https://doi.org/10.1038/nmeth.4301
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DOI: https://doi.org/10.1038/nmeth.4301