A precomputed database of lineage-restricted reference genes yields a fast and accurate tool that uses sequence similarity alone to compute clade abundances from shotgun metagenomic data sets.
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Haft, D., Tovchigrechko, A. High-speed microbial community profiling. Nat Methods 9, 793–794 (2012). https://doi.org/10.1038/nmeth.2080
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DOI: https://doi.org/10.1038/nmeth.2080
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