Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Beyond the rainbow: new fluorescent proteins brighten the infrared scene

Two fluorescent proteins that emit in the far-red and infrared range for imaging applications in cells and in vivo are described.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Fluorescent proteins used for deep-tissue imaging in mammals.

References

  1. Subach, O.M. et al. Nat. Methods 8, 771–777 (2011).

    Article  CAS  Google Scholar 

  2. Filonov, G.S. et al. Nat. Biotechnol. 29, 757–761 (2011).

    Article  CAS  Google Scholar 

  3. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W.W. & Prasher, D.C. Science 263, 802–805 (1994).

    Article  CAS  Google Scholar 

  4. Prasher, D.C., Eckenrode, V.K., Ward, W.W., Prendergast, F.G. & Cormier, M.J. Gene 111, 229–233 (1992).

    Article  CAS  Google Scholar 

  5. Deliolanis, N.C. et al. J. Biomed. Opt. 13, 044008 (2008).

    Article  Google Scholar 

  6. Shu, X., Shaner, N.C., Yarbrough, C.A., Tsien, R.Y. & Remington, S.J. Biochemistry 45, 9639–9647 (2006).

    Article  CAS  Google Scholar 

  7. Kedrin, D. et al. Nat. Methods 5, 1019–1021 (2008).

    Article  CAS  Google Scholar 

  8. Lin, M.Z. et al. Chem. Biol. 16, 1169–1179 (2009).

    Article  CAS  Google Scholar 

  9. Morozova, K.S. et al. Biophys. J. 99, L13–L15 (2010).

    Article  CAS  Google Scholar 

  10. Shcherbo, D. et al. Nat. Methods 7, 827–829 (2010).

    Article  CAS  Google Scholar 

  11. Fischer, A.J. & Lagarias, J.C. Proc. Natl. Acad. Sci. USA 101, 17334–17339 (2004).

    Article  CAS  Google Scholar 

  12. Shu, X. et al. Science 324, 804–807 (2009).

    Article  Google Scholar 

  13. Toh, K.C., Stojkovic, E.A., van Stokkum, I.H., Moffat, K. & Kennis, J.T. Phys. Chem. Chem. Phys. 13, 11985–11997 (2011).

    Article  CAS  Google Scholar 

  14. Sakaue-Sawano, A. et al. Cell 132, 487–498 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael Z Lin.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lin, M. Beyond the rainbow: new fluorescent proteins brighten the infrared scene. Nat Methods 8, 726–728 (2011). https://doi.org/10.1038/nmeth.1678

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.1678

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing