There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFβ signaling, and revealed possible competitive interactors of p53 and c-Jun.
This work was supported by the European Union Sixth Framework Programme grant European Network for Functional Integration (LSHG-CT-2005-518254), Sigrid Jusélius Foundation, University of Helsinki's Research Funds, Academy of Finland (projects 125826, 213345 and 1121413), Finnish Cancer Association, Emil Aaltonen Foundation and competitive research funding of the Pirkanmaa Hospital District.
Classification of discarded interactions in the two case studies.