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Bioimaging

Illuminating the deep

Nature Materials volume 12, pages 285–287 (2013)Cite this article

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Three-photon imaging enables deeper tissue penetration in vivo, however, a lack of imaging probes has restricted its use. Now, this problem has been overcome by engineering non-toxic manganese-doped quantum dots.

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Figure 1: A Jablonski diagram comparing one-, two- and three-photon fluorescence of quantum dots.
Figure 2: Three-photon fluorescence microscopy improves tissue penetration depth and resolution in vivo.

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Authors and Affiliations

  1. Department of Chemical Engineering, Kyryl Zagorovsky and Warren C. W. Chan are in the Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, Materials Science and Engineering, and Chemistry, 160 College Street, Room 450, Toronto, Ontario M5S 3E1, Canada,

    Kyryl Zagorovsky & Warren C. W. Chan

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  1. Kyryl Zagorovsky
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  2. Warren C. W. Chan
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Correspondence to Warren C. W. Chan.

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Zagorovsky, K., Chan, W. Illuminating the deep. Nature Mater 12, 285–287 (2013). https://doi.org/10.1038/nmat3608

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