Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Polymer hydrogels

Chaperoning vaccines

Nature Materials volume 9, pages 537–538 (2010)Cite this article

Subjects

A cationic nanosized hydrogel (nanogel) shows controlled antigen delivery in vivo following intranasal administration and hence holds promise for a clinically effective adjuvant-free and needle-free vaccine system.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Fluorescence images showing sustained antigen delivery to the nasal passage of mice.

References

  1. WHO Fact Sheet 234 (1999); available at http://www.who.int/inf-fs/en/fact234.html

  2. WHO Fact Sheet 231 (2002); available at http://www.who.int/inf-fs/en/fact231.html

  3. Hutin, Y. J. F. & Chen, R. T. B. World Health Organ. 77, 787–788 (1999).

    CAS  Google Scholar 

  4. Levine, M. M. Nature Med. 9, 99–103 (2003).

    Article  CAS  Google Scholar 

  5. Logullo, P., Barbosa de Carvalho, H., Saconi, R. & Massad, E. Vaccine 26, 141–143 (2008).

    Article  Google Scholar 

  6. Nochi, T. et al. Nature Mater. 9, 572–578 (2010).

    Article  CAS  Google Scholar 

  7. Iwasaki, A. & Medzhitov, R. Science 327, 291–295 (2010).

    Article  CAS  Google Scholar 

  8. Sun, J. B., Czerkinsky, C. & Holmgren, J. Scand J. Immunol. 71, 1–11 (2010).

    Article  CAS  Google Scholar 

  9. van Ginkel, F. W., Jackson, R. J., Yuki, Y. & McGhee, J. R. J. Immunol. 165, 4778–4782 (2000).

    Article  CAS  Google Scholar 

  10. Lewis, D. J. et al. PLoS One 4, e6999 (2009).

    Article  Google Scholar 

  11. Mutsch, M. et al. N. Engl. J. Med. 350, 896–903 (2004).

    Article  CAS  Google Scholar 

  12. Akiyoshi, K. et al. J. Control. Release 54, 313–320 (1998).

    Article  CAS  Google Scholar 

  13. Ayame, H., Morimoto, N. & Akiyoshi, K. Bioconjug. Chem. 19, 882–890 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Herman F. Staats is in the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA herman.staats@duke.edu,

    Herman F. Staats

  2. Kam W. Leong is in the Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA. kam.leong@duke.edu,

    Kam W. Leong

Authors
  1. Herman F. Staats
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kam W. Leong
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Staats, H., Leong, K. Chaperoning vaccines. Nature Mater 9, 537–538 (2010). https://doi.org/10.1038/nmat2788

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat2788

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing