Experiments have shown that the physical characteristics of the matrix surrounding a stem cell can affect its behaviour. This picture gets further complicated by studies of stem cells and their differentiated counterparts that show that the cells' own softness also has a clear role in how they respond to stress.
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Holle, A., Engler, A. Stressed-out stem cells. Nature Mater 9, 4–6 (2010). https://doi.org/10.1038/nmat2589
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DOI: https://doi.org/10.1038/nmat2589