Abstract
Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.
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Ferrara, N., Alitalo, K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 5, 1359–1364 (1999). https://doi.org/10.1038/70928
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DOI: https://doi.org/10.1038/70928
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