The latest trials of a live, oral quadrivalent rhesus rotavirus vaccine may open the door to prevention of rotaviral diarrhea.
Article PDF
References
Kapikian, A.Z., Hoshino, Y., Chanock, R.M. & Perez-Schael, I. Efficacy of a quadrivalent rhesus rotavirus-based human rotavirus vaccine aimed at preventing severe rotavirus diarrhea in infants and young children. J. Infect. Dis. 174, S65–S72 (1996).
Perez-Schael, I. et al. Efficacy of the rhesus rotavirus-based quadrivalent vaccine in infants and young children in Venezuela. N. Engl. J. Med. 337, 1181–1187 (1997).
Joensuu, J. Koskenniemi, E., Pang, X.-L. & Vesikari, T. Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis. Lancet 350, 1205–1209 (1997).
Bishop, R.F., Davidson, G.P., Holmes, I.H. & Ruck, B.J. Virus particles in epithelial cells of duodenal mucosa from children with viral gastroenteritis. Lancet 350, 1281–1283 (1973).
Institute of Medicine The prospects of immunizing against rotavirus p. D1 3-1 to D13-12. In New Vaccine Development: Diseases of Importance in Developing Countries Vol. 2 (National Academy Press, Washington DC, 1986).
Bishop R.F., Barnes G.L., Sipriani E. & Lund J.S. Clinical immunity after neonatal rotavirus infection: a prospective longitudinal study in young children. N. Eng. J. Med. 309, 72–76 (1983).
Velazquez, F.R. et al. Rotavirus infection in infants and protection against subsequent infections. N. Eng. J. Med. 335, 1022–1028 (1996).
Glass, R.I. et al. The epidemiology of rotavirus diarrhea in the United States: surveillance and estimates of disease burden. J. Infect. Dis. 174, S5–S11 (1996).
Smith, J., Haddix A. Teutsch, S. & Glass R.I. Cost effectiveness analysis of a rotavirus immunization program for the United States. Pediatrics 96, 609–615 (1995).
Rennels, M.B. et al. Safety and efficacy of high-dose rhesus-human reassortant rotavirus vaccines—report of the national multicenter trial. Pediatrics 97713 (1996).
Santosham, M. et al. Efficacy and safety of high-dose rhesus-human reassortant rotavirus vaccine in native American populations. J. Ped. 131, 632–638 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Glass, R., Bresee, J., Parashar, U. et al. Rotavirus vaccines at the threshold. Nat Med 3, 1324–1325 (1997). https://doi.org/10.1038/nm1297-1324
Issue Date:
DOI: https://doi.org/10.1038/nm1297-1324
This article is cited by
-
Detection and molecular characterization of zoonotic viruses in swine fecal samples in Italian pig herds
Archives of Virology (2015)
-
Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves
Veterinary Research (2013)
-
Rotaviruses from Canadian farm samples
Archives of Virology (2010)
-
Epidemiology of rotavirus in India
The Indian Journal of Pediatrics (2001)