Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Clarifying the causes of Crohn's

Human and animal research suggests Crohn's disease is a heterogeneous group of disorders and implicates commensal bacteria in genetically determined mucosal T-cell dysregulation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Yang, H. et al. Association of intercellular adhesion molecule-1 (ICAM-1) polymorphisms with subsets of inflammatory bowel disease (IBD) stratified by antineutrophil cytoplasmic antibodies (ANCAs). Gastroenterology 109, 440–448 (1995).

    Article  CAS  Google Scholar 

  2. Vasiliauskas, E.A. et al. Perinuclear antineutrophil cytoplasmic antibodies (pANCA) in patients with Crohn's disease define a clinical subgroup. Gastroenterology 108, A935 (1995).

    Google Scholar 

  3. Berberian, L., Valles-Ayoub, Y., Targan, S.R. & Braun, J. Expression of a novel autoantibody defined by the VH3-15 gene in IBD and Campylobacter jejuni enterocolitis. J. Immun. 153, 3756–3763 (1994).

    CAS  PubMed  Google Scholar 

  4. Castro, R. et al. Inflammatory bowel disease association with an HLA class II DPB1 allele. Am. J. hum. Genet. 57, A161 (1995).

    Google Scholar 

  5. Yang, H., Tyan, D., McElree, C. & Rotter, J.I. Linkage of Crohn's disease to the HLA region is consistently detected by multiple nonparametric approaches. Am. J. hum. Genet. 57, A233 (1995).

    Google Scholar 

  6. Sadlack, B. et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75, 253–261 (1993).

    Article  CAS  Google Scholar 

  7. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263–274 (1993).

    Article  Google Scholar 

  8. Mombaerts, P. et al. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75, 275–282 (1993).

    Article  CAS  Google Scholar 

  9. Ma, A., Datta, M.W., Margosian, E., Horak, I. & Alt, F.W. Inflammatory bowel disease in IL2 deficient mice requires T, but not B lymphocytes. Gastroenterology 108, A867 (1995).

    Google Scholar 

  10. Powrie, F. et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhigh CD4+ T-Cells. Immunity 1, 553–562 (1994).

    Article  CAS  Google Scholar 

  11. Aranda, R., Sydora, B.C. & Kronenberg, M. Phenotypic analysis of the intestinal mucosal lymphocyte population in a lymphocyte transfer model of inflammatory bowel disease. Gastroenterology 108, A773 (1995).

    Article  Google Scholar 

  12. Lifrak, E.T., Erickson, R.A., Halbur, L. & Quimbo, E. Role of tumor necrosis factor α in NSAID induced intestinal inflammation. Gastroenterology 108, A149 (1995).

    Google Scholar 

  13. Plevy, S.E., Targan, S.R., Rotter, J.I. & Toyoda, H. Tumor necrosis factor microsatellite associations within HLA-DR2+ patients define Crohn's disease and ulcerative colitis-specific genotypes. Gastroenterology 106, A754 (1994).

    Google Scholar 

  14. Plevy, S.E. et al. The tumor necrosis factor (TNF) microsatellite haplotype a2b1c2d4e1 correlates with increased TNF production in Crohn's disease. Gastroenterology 108, A895 (1995).

    Google Scholar 

  15. Plevy, S., Targan, S.R., Deem, R.L. & Toyoda, H. Increased mucosal TNFαmRNA levels and numbers of TNFα producing cells are unique to Crohn's disease. Gastroenterology 106, A754 (1994).

    Google Scholar 

  16. van Dullemen, H.M. et al. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109, 129–135 (1995).

    Article  CAS  Google Scholar 

  17. Ina, K., Binion, D.G., West, G.A., Dobrea, G.M. & Fiocchi, C. Crohn's disease mucosal T-cells are resistant to apoptosis. Gastroenterology 108, A841 (1995).

    Article  Google Scholar 

  18. Taurog, J.D. et al. The germfree state prevents development of gut and joint inflammatory disease in HLAB2 transgenic rats. J. exp. Med. 180, 2359–2364 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Targan, S., Karp Murphy, L. Clarifying the causes of Crohn's. Nat Med 1, 1241–1243 (1995). https://doi.org/10.1038/nm1295-1241

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1295-1241

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing