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Two immune arms to stop one gut

Postoperative ileus complicates the recovery from intestinal surgery with a great economic burden. How this morbid condition spreads throughout the entire gut remains unknown, but new findings show that a T helper type 1 (TH1)-mediated immune response is involved. Its components may be possible therapeutic targets (pages 1407–1413).

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Figure 1: Proposed pathway of memory TH1 cell dissemination of postoperative ileus (POI).

Marina Corral

References

  1. Kalff, J.C., Schraut, W.H., Simmons, R.L. & Bauer, A.J. Ann. Surg. 228, 652–663 (1998).

    Article  CAS  Google Scholar 

  2. Wehner, S. et al. Gastroenterology 136, 619–629 (2009).

    Article  CAS  Google Scholar 

  3. Kalff, J.C. et al. Ann. Surg. 237, 301–315 (2003).

    PubMed  PubMed Central  Google Scholar 

  4. Bauer, A.J. Neurogastroenterol. Motil. 20 Suppl 1, 81–90 (2008).

    Article  CAS  Google Scholar 

  5. Stoffels, B. et al. Gut 58, 648–660 (2009).

    Article  CAS  Google Scholar 

  6. Boeckxstaens, G.E. & de Jonge, W.J. Gut 58, 1300–1311 (2009).

    Article  CAS  Google Scholar 

  7. Engel, D.R. et al. Nat. Med. 16, 1407–1413 (2010).

    Article  CAS  Google Scholar 

  8. Schwarz, N.T. et al. Gastroenterology 126, 159–169 (2004).

    Article  CAS  Google Scholar 

  9. Schaefer, N. et al. Transpl. Int. 21, 778–791 (2008).

    Article  CAS  Google Scholar 

  10. Probst, H.C. et al. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin. Exp. Immunol. 141, 398–404 (2005).

    Article  CAS  Google Scholar 

  11. Szabo, S.J. et al. Cell 100, 655–669 (2000).

    Article  CAS  Google Scholar 

  12. Kalff, J.C., Schraut, W.H., Billiar, T.R., Simmons, R.L. & Bauer, A.J. Gastroenterology 118, 316–327 (2000).

    Article  CAS  Google Scholar 

  13. Kehlet, H. & Wilmore, D.W. Br. J. Surg. 92, 3–4 (2005).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Anthony J Bauer.

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Bauer, A. Two immune arms to stop one gut. Nat Med 16, 1378–1379 (2010). https://doi.org/10.1038/nm1210-1378

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