A protein has been identified that promotes the formation of osteoclasts, bone-degrading cells—while also inhibiting osteoblasts, bone-forming cells. The findings could lead to new avenues of drug development to strengthen bone (pages 1403–1409).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
Nature Communications Open Access 21 October 2014
-
Osteoclast Fusion and Fission
Calcified Tissue International Open Access 25 April 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Martin, T.J. & Sims, N.A. Trends Mol. Med. 11, 76–81 (2005).
Lee, S.H. et al. Nat. Med. 12, 1403–1409 (2006).
Teitelbaum, S.L. Science 289, 1504–1508 (2000).
Takayanagi, H. J. Mol. Med. 83, 170–179 (2005).
Howard, G.A., Bottemiller, B.L., Turner, R.T., Rader, J.I. & Baylink, D.J. Proc. Natl. Acad. Sci. USA 78, 3204–3208 (1981).
Sun-Wada, G.H., Yoshimizu, T., Imai-Senga, Y., Wada, Y. & Futai, M. Gene 302, 147–153 (2003).
Yagi, M. et al. J. Exp. Med. 202, 345–351 (2005).
Zhao, C. et al. Cell Metab. 4, 111–121 (2006).
Russell, R.G. Ann. NY Acad. Sci. 1068, 367–401 (2006).
Khosla, S. N. Engl. J. Med. 349, 1277–1279 (2003).
Martin, T.J. et al. Ann. NY Acad. Sci. 1068, 458–470 (2006).
Boyce, B.F., Schwarz, E.M. & Xing, L. Curr. Opin. Rheumatol. 18, 427–432 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Boyce, B., Xing, L. Osteoclasts, no longer osteoblast slaves. Nat Med 12, 1356–1358 (2006). https://doi.org/10.1038/nm1206-1356
Issue Date:
DOI: https://doi.org/10.1038/nm1206-1356
This article is cited by
-
Chinese Immigrant Mothers of Children with Developmental Disabilities: Stressors and Social Support
International Journal of Mental Health and Addiction (2021)
-
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
Nature Communications (2014)
-
Osteoclast Fusion and Fission
Calcified Tissue International (2012)
-
Dimorphic effects of Notch signaling in bone homeostasis
Nature Medicine (2008)