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Antibody diversity: one enzyme to rule them all

Nature Medicine volume 10, pages 1304–1305 (2004)Cite this article

Three reactions diversify antibody genes in human somatic cells of the B lineage: VDJ recombination, somatic hypermutation and class-switch recombination. The discovery of activation-induced cytidine deaminase (AID) has led to the elucidation of a unified molecular mechanism for initiation of the last two reactions and suggests why B cells undergoing these reactions are prone to cancer-associated DNA damage.

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Figure 1: Antibody diversification.

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Authors and Affiliations

  1. Laboratory of Molecular Immunology and the Howard Hughes Medical Institute, The Rockefeller University, New York, 10021, New York, USA

    Michel C Nussenzweig

  2. The Center for Blood Research and Department of Genetics, Howard Hughes Medical Institute, The Children's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Frederick W Alt

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  1. Michel C Nussenzweig
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  2. Frederick W Alt
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Nussenzweig, M., Alt, F. Antibody diversity: one enzyme to rule them all. Nat Med 10, 1304–1305 (2004). https://doi.org/10.1038/nm1204-1304

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