Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A new feature on the cholesterol-lowering landscape

Reduction in blood levels of low-density lipoprotein cholesterol reduces the risk of coronary heart disease. The identification of a new class of compounds that upregulate the low-density lipoprotein receptor may lead to new therapeutic advances. (pages 1332–1338)

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The regulation of cholesterol metabolism in the liver cell and the body.

References

  1. Grundy, S.M. Statin trials and goals of cholesterol-lowering therapy. Circulation 97, 1436–1439 (1998).

    Article  CAS  Google Scholar 

  2. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285, 2486–2497 (2001).

  3. Grand-Perret, T. et al. SCAP ligands are potent new lipid lowering drugs. Nature Med. 7, 1332–1338 (2001).

    Article  CAS  Google Scholar 

  4. Brown, M.S. & Goldstein, J.L. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. USA 96, 11041–11048 (1999).

    Article  CAS  Google Scholar 

  5. Edwards, P.A., Tabor, D., Kast, H.R. & Venkateswaran, A. Regulation of gene expression by SREBP and SCAP. Biochim. Biophys. Acta 1529, 103–113 (2000).

    Article  CAS  Google Scholar 

  6. Korn, B.S. et al. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). J. Clin. Invest. 102, 2050–2060 (1998).

    Article  CAS  Google Scholar 

  7. Sheng, Z., Otani, H., Brown, M.S. & Goldstein, J.L. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA 92, 935–938 (1995).

    Article  CAS  Google Scholar 

  8. Repa, J.J. et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev. 14, 2819–2830 (2000).

    Article  CAS  Google Scholar 

  9. Izzat, N.N., Deshazer, M.E. & Loose-Mitchell, D.S. New molecular targets for cholesterol-lowering therapy. J. Pharmacol. Exp. Ther. 293, 315–320 (2000).

    CAS  PubMed  Google Scholar 

  10. Bays, H.E. et al. Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: pooled analysis of two phase II studies. Clin. Ther. 23, 1209–1230 (2001).

    Article  CAS  Google Scholar 

  11. Wetterau, J.R. et al. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 282, 751–754 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rader, D. A new feature on the cholesterol-lowering landscape. Nat Med 7, 1282–1284 (2001). https://doi.org/10.1038/nm1201-1282

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1201-1282

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing