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The physiological response to cardiovascular 'orphan' G protein-coupled receptor agonists

Nature Medicine volume 5, pages 1241–1242 (1999)Cite this article

Abstract

Cardiac pressor agents typically reduce the amount of blood pumped with each heartbeat. Cardiovascular hemodynamic principles can show whether such a response is physiologic or maladaptive.

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Figure 1: Left ventricular pressure–volume loops depicting one cardiac cycle.

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Authors and Affiliations

  1. Department of Medicine Cardiology Division, Johns Hopkins Medical Institutions, Baltimore, 21287 , Maryland, USA

    Joshua M. Hare & David A. Kass

  2. Howard Hughes Medical Institute and Department of Medicine Cardiology and Pulmonary Divisions Duke University Medical Center, Durham, 27710, North Carolina, USA

    Jonathan S. Stamler

Authors
  1. Joshua M. Hare
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  2. David A. Kass
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  3. Jonathan S. Stamler
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Hare, J., Kass, D. & Stamler, J. The physiological response to cardiovascular 'orphan' G protein-coupled receptor agonists. Nat Med 5, 1241–1242 (1999). https://doi.org/10.1038/15193

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