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A polymeric form of fibronectin has antimetastatic effects against multiple tumor types

Nature Medicine volume 2, pages 1197–1203 (1996)Cite this article

Abstract

Metastasis accounts for most deaths in cancer patients. Tumor cell adhesion to the extracellular matrix through integrins is thought to be a critical step in metastasis and a potential target for therapeutic intervention. We show here that treatment of human osteosarcoma, melanoma and carcinoma cells with a polymeric form of fibronectin (sFN), before inoculation into nude mice, prevented tumor formation. Intraperitoneally administered sFN significantly reduced lung colonization from intravenously injected tumor cells (experimental metastasis) and from subcutaneous tumors in nude mice (spontaneous metastasis). Treatment with sFN blocked cell spreading and migration in vitro suggesting a possible mechanism for the antimetastatic effect.

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Authors and Affiliations

  1. La Jolia Cancer Research Center, The Bumham Institute, 10901 North Torrey Pines Road, La Jolla, California, 92037, USA

    Renata Pasqualini, Sandrine Bourdoulous & Erkki Ruoslahti

  2. School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, California, 92093, USA

    Virgil L. Woods Jr.

  3. Department of Biosciences, Division of Biochemistry, University of Helsinki, Viikinkaari 5, 00014, Finland

    Erkki Koivunen

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  1. Renata Pasqualini
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  4. Virgil L. Woods Jr.
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  5. Erkki Ruoslahti
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Pasqualini, R., Bourdoulous, S., Koivunen, E. et al. A polymeric form of fibronectin has antimetastatic effects against multiple tumor types. Nat Med 2, 1197–1203 (1996). https://doi.org/10.1038/nm1196-1197

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