New findings suggest that PARP may be a perpetrator of brain injury following ischemic insult (pages 1089–1095).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Choi, D.W. Excitotoxic cell death. J Neurobiol 23, 1261–1276 (1992).
Dawson, V.L., Dawson, T.M., London, E.D., Bredt, D.S. & Snyder, S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88, 6368–6371 (1991).
Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A. & Freeman, B.A. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87, 1620–1624 (1990).
Zhang, J. Dawson, V.L., Dawson, T.M. & Snyder, S.H. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263, 687–689 (1994).
Eliasson, M.J.L. et al. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nature Med. 3, 1089–1095 (1997).
Endres, M., Wang, Z.-Q., Namura, S., Waeber, C. & Moskowitz, M.A. Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase. J. Cereb Blood Flow Metab, in the press.
Du, C. et al. Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia. Brain Res 718, 233–236 (1996).
Wang, Z.Q. et al. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 9, 509–520 (1995).
Schauwecker, P.E. & Steward, O. Genetic determinants of susceptibility to excitotoxic cell death. Proc Natl Acad Sci USA 94, 4103–4108 (1997).
Gerlai, R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19, 177–181 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Choi, D. At the scene of ischemic brain injury: Is PARP a perp?. Nat Med 3, 1073–1074 (1997). https://doi.org/10.1038/nm1097-1073
Issue Date:
DOI: https://doi.org/10.1038/nm1097-1073