Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HIF, a missing link between metabolism and cancer

Nature Medicine volume 11, pages 1047–1048 (2005)Cite this article

Mutations in metabolic enzymes lead to changes in stability of HIF, highlighting the connection between metabolism and cancer.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Increases in metabolic intermediates lead to HIF stabilization.

Katie Ris

References

  1. Tomlinson, I.P. et al. Nat. Genet. 30, 406–410 (2002).

    Article  CAS  Google Scholar 

  2. Eng, C. et al. Nat. Rev. Cancer 3, 193–202 (2003).

    Article  CAS  Google Scholar 

  3. Isaacs, J.S. et al. Cancer Cell 8, 143–153 (2005).

    Article  CAS  Google Scholar 

  4. Semenza, G.L. Nat. Rev. Cancer 3, 721–732 (2003).

    Article  CAS  Google Scholar 

  5. Maxwell, P.H. et al. Nature 399, 271–275 (1999).

    Article  CAS  Google Scholar 

  6. Garber, K. J. Natl. Cancer Inst. 96, 1805–1806 (2004).

    Article  Google Scholar 

  7. Harris, A.L. Nat. Rev. Cancer 2, 38–47 (2002).

    Article  CAS  Google Scholar 

  8. Selak, M.A. et al. Cancer Cell 7, 77–85 (2005).

    Article  CAS  Google Scholar 

  9. Pollard, P.J. et al. Hum. Mol. Genet. 14, 2231–2239 (2005).

    Article  CAS  Google Scholar 

  10. Schofield, C.J. & Ratcliffe, P.J. Nat. Rev. Mol. Cell Biol. 5, 343–354 (2004).

    Article  CAS  Google Scholar 

  11. Lee, S. et al. Cancer Cell 8, 155–167 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Renal Section, Hammersmith Hospital, Imperial College London, London, W12 0NN, UK

    Miguel A Esteban & Patrick H Maxwell

Authors
  1. Miguel A Esteban
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Patrick H Maxwell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Esteban, M., Maxwell, P. HIF, a missing link between metabolism and cancer. Nat Med 11, 1047–1048 (2005). https://doi.org/10.1038/nm1005-1047

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1005-1047

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing