Overeating can lead to the development of insulin resistance and diabetes. A component of the mTOR nutrient signaling pathway now bridges the mechanistic gap between obesity and insulin resistance.
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References
World Health Organization. World Health Organization Global Strategy on Diet, Physical Activity, and Health. 2003. http://www.who.int/dietphysicalactivity/en/
Boden, G. & Carnell, L.H. Best Pract. Res. Clin. Endocrinol. Metab. 17, 399–410 (2003).
Patti, M.E. Curr. Diab. Rep. 4, 176–181 (2004).
Um, S.H. et al. Nature 431, 200–205 (2004).
Fingar, D.C. & Blenis, J. Oncogene 23, 3151–3171 (2004).
Kershaw, E.E. & Flier, J.S. J. Clin. Endocrinol. Metab. 89, 2548–2556 (2004).
Abel, E.D. et al. Nature 409, 729–733 (2001).
Bluher, M., Kahn, B.B. & Kahn, C.R. Science 299, 572–574 (2003).
Obici, S. et al. J. Clin. Invest. 109, 1599–1605 (2002).
Pegorier, J.P., May, C.L. & Girard, J. J. Nutr. 134, 2444S–2449S (2004).
Patti, M.E., Brambilla, E., Luzi, L., Landaker, E.J. & Kahn, C.R. J. Clin. Invest. 101, 1519–1529 (1998).
Pende, M. et al. Nature 408, 994–997 (2000).
Hardie, D.G. Endocrinology 144, 5179–5183 (2003).
Carlson, C.J., White, M.F. & Rondinone, C.M. Biochem. Biophys. Res. Commun. 316, 533–539 (2004).
Harrington, L.S. et al. J. Cell Biol. 166, 213–223 (2004).
Shah, O.J. et al. Curr. Biol. Published online 19 August 2004 (doi:10.1016/S0960982204006116).
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Patti, ME., Kahn, B. Nutrient sensor links obesity with diabetes risk. Nat Med 10, 1049–1050 (2004). https://doi.org/10.1038/nm1004-1049
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DOI: https://doi.org/10.1038/nm1004-1049
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