Retinoids have a wide variety of biological functions and have been recently shown to regulate cholesterol transport, bile acid synthesis and cholesterol absorption. These findings indicate a new line of mechanisms to control cholesterol homeostasis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Repa, J.J. et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289, 1524–1529 (2000).
Mukherjee, R. et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 386, 407–410 (1997).
Makishima, M. et al. Identification of a nuclear receptor for bile acids. Science 284, 1362–1365 (1999).
Brooks-Wilson, A. et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nature Genet. 22, 336–345 (1999).
Wang, N., Silver, D.L., Costet, P. & Tall, A.R. Specific binding of apoA-I, enhanced cholesterol efflux and altered plasma membrane morphology in cells expressing ABC1. J. Biol. Chem. (in the press).
Langmann, T. et al. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem. Biophys. Res. Commun. 257, 29–33 (1999).
Costet, P., Luo, Y., Wang, N. & Tall, A.R. Sterol-dependent transactivation of the human ABC1 promoter by LXR/RXR. J. Biol. Chem. 275, 28240–28245 (2000).
McNeish, J. et al. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc. Natl. Acad. Sci. USA 97, 4245–4250 (2000).
Luo, Y. & Tall, A.R. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J. Clin. Invest. 105, 513–520 (2000).
Peet, D.J. et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93, 693–704 (1998).
Sehayek, E. et al. Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proc. Natl. Acad. Sci. USA 95, 10194–10199 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tall, A., Costet, P. & Luo, Y. ‘Orphans’ meet cholesterol. Nat Med 6, 1104–1105 (2000). https://doi.org/10.1038/80433
Issue Date:
DOI: https://doi.org/10.1038/80433
This article is cited by
-
ABCA1, from pathology to membrane function
Pflügers Archiv - European Journal of Physiology (2007)