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Heart and lung disease in engineered mice

Nature Medicine volume 1, pages 749–751 (1995)Cite this article

Technological miniaturization combined with the power of molecular genetics makes the mouse a model animal for understanding human cardiovascular and pulmonary diseases.

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References

  1. Rockman, H.A. et al. Segregation of atrial specific and inducible expression of an ANF transgene in an in vivo murine model of cardiac hypertrophy. Proc. natn. Acad. Sci. U.S.A. 88, 8277–8281 (1991).

    Article  CAS  Google Scholar 

  2. Chien, K.R. Molecular advances in cardiovascular biology. Science 260, 916–917 (1993).

    Article  CAS  Google Scholar 

  3. Rockman, H.A. et al. Molecular and physiological alterations in murine ventricular dysfunction. Proc. natn. Acad. Sci. U.S.A. 91, 2694–2698 (1994).

    Article  CAS  Google Scholar 

  4. Chien, K.R., Cardiac muscle diseases in genetically engineered mice. Am. J. Physiol. (in the press).

  5. Milano, C.A. et al. Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor. Science 264, 582–586 (1994).

    Article  CAS  Google Scholar 

  6. Bond, R.A. et al. Physiologic effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor. Nature 374, 272–275 (1995).

    Article  CAS  Google Scholar 

  7. Koch, W.J. et al. Reciprocally altered cardiac function in transgenic mice overexpressing the β2-adrenergic receptor kinase or a βARK inhibitor. Science 268, 1350–1353 (1995).

    Article  CAS  Google Scholar 

  8. Dyson, E. et al. Atrial-like phenotype is associated with embryonic ventricular failure in RXRα −/− mice. Proc. natn. Acad. Sci. U.S.A. 92, 7386–7390 (1995).

    Article  CAS  Google Scholar 

  9. John, S.W. et al. Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science 267, 679–681 (1995).

    Article  CAS  Google Scholar 

  10. Kim, H.S. et al. Genetic control of blood pressure and the angiotensinogen locus. Proc. natn. Acad. Sci, U.S.A. 92, 2735–2739 (1995).

    Article  CAS  Google Scholar 

  11. Krege, J.H. et al. Male-female differences in fertility and blood pressures in ACE deficient mice. Nature 315, 146–148 (1995).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland, 20892, USA

    Michael C. Lin

  2. Department of Medicine, University of California at San Diego, La Jolla, California, 92093, USA

    Howard A. Rockman

  3. Department of Medicine, Center for Molecular Genetics, American Heart Association–Bugher Foundation Center for Molecular Biology, University of California at San Diego, La Jolla, California, 92093, USA

    Kenneth R. Chien

Authors
  1. Michael C. Lin
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  2. Howard A. Rockman
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  3. Kenneth R. Chien
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Lin, M., Rockman, H. & Chien, K. Heart and lung disease in engineered mice. Nat Med 1, 749–751 (1995). https://doi.org/10.1038/nm0895-749

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