Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Putting pressure on pre-eclampsia

Nature Medicine volume 14, pages 810–812 (2008)Cite this article

Women with pre-eclampsia, a potentially deadly complication of pregnancy, produce agonistic autoantibodies against angiotensin receptor-1, a transmembrane protein that regulates blood pressure. Findings in mice suggest how these antibodies might help trigger the condition (pages 855–862).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Angiotensin receptor autoantibodies (AT1-AAs) in pre-eclampsia.

Katie Ris-Vicari

References

  1. Sibai, B., Dekker, G. & Kupferminc, M. Lancet 365, 785–799 (2005).

    Article  Google Scholar 

  2. Zhou, C.C. et al. Nat. Med. 14, 855–862 (2008).

    Article  CAS  Google Scholar 

  3. Wallukat, G. et al. J. Clin. Invest. 103, 945–952 (1999).

    Article  CAS  Google Scholar 

  4. Herse, F. et al. J. Mol. Med. 86, 697–703 (2008).

    Article  CAS  Google Scholar 

  5. Dragun, D. et al. N. Engl. J. Med. 352, 558–569 (2005).

    Article  CAS  Google Scholar 

  6. Dechend, R. et al. Hypertension 45, 742–746 (2005).

    Article  CAS  Google Scholar 

  7. Herse, F. et al. Hypertension 49, 604–611 (2007).

    Article  CAS  Google Scholar 

  8. Fonseca, J.E., Mendez, F., Catano, C. & Arias, F. Am. J. Obstet. Gynecol. 193, 1591–1598 (2005).

    Article  CAS  Google Scholar 

  9. Martin, J.N. Jr et al. J. Clin. Apher. 9, 155–161 (1994).

    Article  Google Scholar 

  10. Gant, N.F., Daley, G.L., Chand, S., Whalley, P.J. & MacDonald, P.C. J. Clin. Invest. 52, 2682–2689 (1973).

    Article  CAS  Google Scholar 

  11. Maynard, S., Epstein, F.H. & Karumanchi, S.A. Annu. Rev. Med. 59, 61–78 (2008).

    Article  CAS  Google Scholar 

  12. Venkatesha, S. et al. Nat. Med. 12, 642–649 (2006).

    Article  CAS  Google Scholar 

  13. Levine, R.J. et al. N. Engl. J. Med. 355, 992–1005 (2006).

    Article  CAS  Google Scholar 

  14. Cudmore, M. et al. Circulation 115, 1789–1797 (2007).

    Article  CAS  Google Scholar 

  15. Redman, C.W. & Sargent, I.L. Science 308, 1592–1594 (2005).

    Article  CAS  Google Scholar 

  16. Kanasaki, K. et al. Nature 453, 1117–1121 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Samir M. Parikh is in the Department of Medicine Beth, Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.,

    Samir M Parikh

  2. S. Ananth Karumanchi is in the Departments of Medicine and Obstetrics and Gynecology and the Howard Hughes Medical Institute at Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. sananth@bidmc.harvard.edu,

    S Ananth Karumanchi

Authors
  1. Samir M Parikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Ananth Karumanchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parikh, S., Karumanchi, S. Putting pressure on pre-eclampsia. Nat Med 14, 810–812 (2008). https://doi.org/10.1038/nm0808-810

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0808-810

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing