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Breast cancer progression with a Twist

Can tumor progression be understood in terms of the redeployment of mechanisms used in embryonic development? The identification of Twist, a bHLH transcription factor, as a protein linked to metastases in breast cancers would suggest so.

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Figure 1: Twist and breast cancer progression.
Figure 2: High Twist expression occurs in invasive lobular carcinoma (ILC).

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Thiery, J., Morgan, M. Breast cancer progression with a Twist. Nat Med 10, 777–778 (2004). https://doi.org/10.1038/nm0804-777

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