Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Urgently needed: a filter for the HIV-1 vaccine pipeline

Nature Medicine volume 10, pages 769–771 (2004)Cite this article

Research groups worldwide are trying to make immunogens intended to elicit neutralizing antibody responses as part of a prophylactic vaccine to counter the spread of HIV-1. The relative merits of different designs can only be gauged properly through comparative studies, and particularly by evaluating human or animal antisera under identical, or comparable, conditions. Hence there is a need for assay standardization and for the creation of a centralized testing facility that could distribute consensus protocols and reagents.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Letvin, N.L. & Walker, B.D. Nat. Med. 9, 861–866 (2003).

    Article  CAS  Google Scholar 

  2. McMichael, A.J. & Hanke, T. Nat. Med. 9, 874–880 (2003).

    Article  CAS  Google Scholar 

  3. Burton, D.R. et al. Nat. Immunol. 5, 233–236 (2004).

    Article  CAS  Google Scholar 

  4. Collis, A.V., Brouwer, A.P. & Martin, A.C. J. Mol. Biol. 325, 337–354 (2003).

    Article  CAS  Google Scholar 

  5. Wu, T.T., Johnson, G. & Kabat, E.A. Proteins 16, 1–7 (1993).

    Article  CAS  Google Scholar 

  6. Parren, P.W.H.I. & Burton, D.R. Adv. Immunol. 77, 195–262 (2001).

    Article  CAS  Google Scholar 

  7. Klasse, P.J. & Sattentau, Q.J. J. Gen. Virol. 83, 2091–2108 (2002).

    Article  CAS  Google Scholar 

  8. Mascola, J.R. Vaccine 20, 1922–1925 (2002).

    Article  CAS  Google Scholar 

  9. Dreyer, K. et al. AIDS Res. Hum. Retroviruses 15, 1563–1571 (1999).

    Article  CAS  Google Scholar 

  10. Spenlehauer, C., Gordon, C.A., Trkola A. & Moore, J.P. Virology 280, 292–300 (2001).

    Article  CAS  Google Scholar 

  11. Wei, X. et al. Antimicrob. Agents Chemother. 46, 1896–1905 (2002).

  12. Mascola, J.R. et al. J. Virol. 76, 4810–4821 (2002).

    Article  CAS  Google Scholar 

  13. Richman, D.D., Wrin, T., Little, S.J. & Petropoulos, C.J. Proc. Natl. Acad. Sci. USA 100, 4144–4149 (2003).

    Article  CAS  Google Scholar 

  14. Klausner, R.D. et al. Science 300, 2036–2039 (2003).

    Article  CAS  Google Scholar 

  15. Moore, J.P., Parren, P.W.H.I. & Burton, D.R. J. Virol. 75, 5721–5729 (2001).

    Article  CAS  Google Scholar 

  16. Pugach, P. et al. Virology 321, 8–22 (2004).

    Article  CAS  Google Scholar 

  17. Derdeyn, C.A. et al. Science 303, 2019–2022 (2004).

    Article  CAS  Google Scholar 

  18. D'Souza, M.P., Livnat, D., Bradac, J.A. & Bridges, S.H. J. Infect. Dis. 175, 1056–1062 (1997).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank J. Mascola, D. Montefiori and R. Wyatt for helpful comments. Research on HIV-1 vaccine projects in the authors' laboratories is supported by the US National Institutes of Health and by the International AIDS Vaccine Initiative.

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

    John P Moore

  2. Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA

    Dennis R Burton

Authors
  1. John P Moore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dennis R Burton
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moore, J., Burton, D. Urgently needed: a filter for the HIV-1 vaccine pipeline. Nat Med 10, 769–771 (2004). https://doi.org/10.1038/nm0804-769

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0804-769

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing