Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Fighting arthritis with a senescence gene

Nature Medicine volume 5, pages 731–732 (1999)Cite this article

Abstract

The senescent phenotype is repressed in rheumatoid arthritis and can be restored by the p16INK4a tumor suppressor gene (pages 760–767).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Taniguchi T. et al. Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis. Nature Med. 5, 760–767 (1999).

    Article  CAS  Google Scholar 

  2. Serrano, M., Hannon, G.J. & Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366, 704–707 (1993).

    Article  CAS  Google Scholar 

  3. Nobori, T. et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368, 753– 756 (1994).

    Article  CAS  Google Scholar 

  4. Sherr, C.J. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984–2991 (1998).

    Article  CAS  Google Scholar 

  5. Chin, L., Pomerantz, J. & DePinho, R.A. The INK4a/ARF tumor suppressor: One gene—two products—two pathways. Trends Biochem. Sci. 23, 291–296 (1998).

    Article  CAS  Google Scholar 

  6. Stein, G.H., Drullinger, L.F., Sonlard, A. & Dulic, V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 19, 2109–2117 (1999).

    Article  CAS  Google Scholar 

  7. Cameron, E.E. et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genet. 21, 103–107 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Sam and Rose Stein Institute for Research on Aging University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0663, California, USA

    Dennis A. Carson & Norio Haneji

Authors
  1. Dennis A. Carson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Norio Haneji
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carson, D., Haneji, N. Fighting arthritis with a senescence gene. Nat Med 5, 731–732 (1999). https://doi.org/10.1038/10447

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/10447

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing