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Prevention of breast tumour development in vivo by downregulation of the p185neureceptor

Nature Medicine volume 1, pages 644–648 (1995)Cite this article

Abstract

Certain strains of transgenic mice that express the rat neu oncogene (neuT) in mammary epithelial cells develop breast tumours at an average of 44 weeks of age. In this study, intraperitoneal injection of a monoclonal anti-receptor antibody specific for the rat neuT oncogene product dramatically affected tumour development in these transgenic mice in a dose-dependent manner. A significant proportion (50%) of mice, when injected with anti-receptor antibodies, did not develop tumours even after 90 weeks of age. The phosphotyrosine levels of the membrane fraction of breast tissues in the anti-receptor antibody-treated mice were almost completely abolished when a higher dose of antibodies was used. This study demonstrates, for the first time, that immunologic manipulation of an oncogene product can effectively prevent the development of tumours in a rodent transgenic model.

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Author information

Author notes

  1. Tadao Okudaira

    Present address: Department of Otolaryngology, Hachioji Medical Center, Tokyo Medical College, Hachiofi, Tokyo, 193, Japan

  2. Douglas P. Clark

    Present address: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, 21287, USA

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, John Morgan Building, University of Pennsylvania, Room 288, Philadelphia, Pennsylvania, 19104, USA

    Makoto Katsumata, Tadao Okudaira, Arabinda Samanta, Douglas P. Clark & Mark I. Greene

  2. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Jeffrey A. Drebin

  3. Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal, Quebec, H2W1R7, Canada

    Paul Jolicoeur

Authors
  1. Makoto Katsumata
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  3. Arabinda Samanta
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  4. Douglas P. Clark
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  5. Jeffrey A. Drebin
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  6. Paul Jolicoeur
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  7. Mark I. Greene
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Katsumata, M., Okudaira, T., Samanta, A. et al. Prevention of breast tumour development in vivo by downregulation of the p185neureceptor. Nat Med 1, 644–648 (1995). https://doi.org/10.1038/nm0795-644

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  • DOI: https://doi.org/10.1038/nm0795-644

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