Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

T-cell dynamics of immunodeficiency

The recent descriptions of T-cell dynamics in HIV disease have refocused efforts to understand the normal homeostatic processes that maintain T-cell populations (pages 674–680).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Margolick, J. et al. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. Nature Med. 1, 674–680 (1995).

    Article  CAS  Google Scholar 

  2. Ho, D. et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123–126 (1995).

    Article  CAS  Google Scholar 

  3. Wei, X. et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373, 117–122 (1995).

    Article  CAS  Google Scholar 

  4. Kovacs, J. et al. Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. New Engl. J. Med. 332, 567–575 (1995).

    Article  CAS  Google Scholar 

  5. Rabin, R.L. et al. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J. clin. Invest 95, 2054–2060 (1995).

    Article  CAS  Google Scholar 

  6. Roederer, M. et al. CD8 naive T cell counts decrease progressively in HIV-infected adults. J. clin. Invest. 95, 2061–2066 (1995).

    Article  CAS  Google Scholar 

  7. Mosier, D. Nature 375, 193–194 (1995).

    Article  CAS  Google Scholar 

  8. Sprent, J. & Tough, D. Nature 375, 194–195 (1995).

    Article  CAS  Google Scholar 

  9. Phillips, A., Sabin, C., Mocroft, A. & Janossy, G. Nature 375, 195 (1995).

    Article  CAS  Google Scholar 

  10. Dimitrov, D. & Martin, M. Nature 375, 194–195 (1995).

    Article  CAS  Google Scholar 

  11. Ho, D., Perelson, A. & Shaw, G. Nature 375, 198 (1995).

    Article  CAS  Google Scholar 

  12. Rocha, B., Dautigny, N. & Pereira, P. Peripheral T lymphocytes: Expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur. J. Immun. 19, 905–911 (1989).

    Article  CAS  Google Scholar 

  13. Katsikis, P., Wunderlich, E., Smith, C., Herzen-berg, L. & Herzenberg, L. Fas antigen stimulation induces marked apoptosis of T lymphocytes in HIV infected individuals. J. exp. Med. 181, 2029–2036 (1995).

    Article  CAS  Google Scholar 

  14. Donnenberg, A., Margolick, J., Beltz, L., Donnenberg, V. & Rinaldo, C. Apoptosis and lymphopoiesis in bone marrow transplantation (BMT) and HIV disease. Res. Immun. (in the press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roederer, M. T-cell dynamics of immunodeficiency. Nat Med 1, 621–622 (1995). https://doi.org/10.1038/nm0795-621

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0795-621

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing