Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Regulatory RNA goes awry in Alzheimer's disease

An antisense RNA may contribute to Alzheimer's disease by upregulating β-secretase (pages 723–730).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Dysregulation of BACE1 and Aβ production in Alzheimer's disease.

Katie Ris-Vicari

References

  1. Faghigi, M.A. et al. Nat. Med. 14, 723–730 (2008).

    Article  Google Scholar 

  2. Vassar, R. et al. Science 286, 735–741 (1999).

    Article  CAS  Google Scholar 

  3. Dahm, R. & Macchi, P. Biol. Cell 99, 649–661 (2007).

    Article  CAS  Google Scholar 

  4. Rossner, S., Sastre, M., Bourne, K. & Lichtenthaler, S.F. Prog. Neurobiol. 79, 95–111 (2006).

    Article  CAS  Google Scholar 

  5. Mowrer, K.R. & Wolfe, M.S. J. Biol. Chem. published online, doi:10.1074/jbc.M801322200 (15 May 2008).

  6. Wang, W.X. et al. J. Neurosci. 28, 1213–1223 (2008).

    Article  Google Scholar 

  7. Hebert, S.S. et al. Proc. Natl. Acad. Sci. USA 105, 6415–6420 (2008).

    Article  CAS  Google Scholar 

  8. Lammich, S., Schobel, S., Zimmer, A.K., Lichtenthaler, S.F. & Haass, C. EMBO Rep. 5, 620–625 (2004).

    Article  CAS  Google Scholar 

  9. He, X., Li, F., Chang, W.P. & Tang, J. J. Biol. Chem. 280, 11696–11703 (2005).

    Article  CAS  Google Scholar 

  10. Puglielli, L., Ellis, B.C., Saunders, A.J. & Kovacs, D.M. J. Biol. Chem. 278, 19777–19783 (2003).

    Article  CAS  Google Scholar 

  11. Ehehalt, R., Keller, P., Haass, C., Thiele, C. & Simons, K. J. Cell Biol. 160, 113–123 (2003).

    Article  CAS  Google Scholar 

  12. Capell, A. et al. J. Biol. Chem. 277, 5637–5643 (2002).

    Article  CAS  Google Scholar 

  13. Willem, M. et al. Science 314, 664–666 (2006).

    Article  CAS  Google Scholar 

  14. Johnston, J.A. et al. Biochem. Soc. Trans. 33, 1096–1100 (2005).

    Article  CAS  Google Scholar 

  15. Wen, Y. et al. Neuron 57, 680–690 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

St George-Hyslop, P., Haass, C. Regulatory RNA goes awry in Alzheimer's disease. Nat Med 14, 711–712 (2008). https://doi.org/10.1038/nm0708-711

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0708-711

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing