The tumor-killing capacity and the systemic toxicity of the cytokine tumor necrosis factor (TNF) have appeared inseparable. Now a study shows that TNF loses its toxicity but still kills tumors in heat-treated mice.
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Leist, M., Jäättelä, M. Burning up TNF toxicity for cancer therapy. Nat Med 8, 667–668 (2002). https://doi.org/10.1038/nm0702-667
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DOI: https://doi.org/10.1038/nm0702-667