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Cartilage to bone—Angiogenesis leads the way

Nature Medicine volume 5, pages 617–618 (1999)Cite this article

Abstract

Vascular endothelial growth factor plays an important part in longitudinal bone growth by stimulating angiogenesis into the epiphyseal growth plate (pages 623–628).

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Figure 1: The long bones grow as the expanding cartilage of the growth plate (GP) is replaced by advancing bone through endochondral ossification.

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Authors and Affiliations

  1. Department of Surgery, Children's Hospital, Harvard Medical School, Boston, 02115 , Massachusetts, USA

    Jay Harper & Michael Klagsbrun

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  1. Jay Harper
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  2. Michael Klagsbrun
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Harper, J., Klagsbrun, M. Cartilage to bone—Angiogenesis leads the way. Nat Med 5, 617–618 (1999). https://doi.org/10.1038/9460

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