Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • On the Market
  • Published:

Gene therapy for therapeutic myocardial angiogenesis: A promising synthesis of two emerging technologies

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Folkman, J. Tumor Angiogenesis: Therapeutic Implications. New Eng. J. Med. 285, 1182–1186(1971).

    Article  CAS  Google Scholar 

  2. Tuder, R.M., Flook, R.E. & Voelkel, N.F. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Fit in lungs exposed to acute or to chronic hypoxia. J. Clin. Invest. 95, 1798–1807 (1995).

    Article  CAS  Google Scholar 

  3. Banai, S. et al. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 89, 2183–2189(1994).

    Article  CAS  Google Scholar 

  4. Bauters, C., et al. Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor. J. Vasc. Surg. 21, 314–325 (1995).

    Article  CAS  Google Scholar 

  5. Takeshita, S. et al. Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation 90, 228–234 (1994).

    Google Scholar 

  6. Henry, T.D. et al. Results of intracoronary recombinant human vascular endothelial growth factor administration trial. J. Am. Coll. Card. 31, 65A (1998).

    Article  Google Scholar 

  7. Klagsbrun, M. The fibroblast growth factor family: Structural and biological properties. Prog. Growth Factor Res. 1, 207–235 (1989).

    Article  CAS  Google Scholar 

  8. Unger, E.F. et al. Basic fibroblast growth factor enhances myocardial collateral flow in canine model. Am. J. Physiol. 266, H1588–1595 (1994).

    CAS  Google Scholar 

  9. Lazarous, D.F. et al. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. Circulation 91, 145–153(1995).

    Article  CAS  Google Scholar 

  10. Lazarous, D.F. et al. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. Circulation 94, 1074–1082 (1996).

    Article  CAS  Google Scholar 

  11. Mazue, G. et al. The histopathology of kidney changes in rats and monkeys following intravenous administration of massive doses of FCE 26184, human basic fibroblast growth factor. Toxicol. Pathol. 21, 490–501 (1993).

    Article  CAS  Google Scholar 

  12. Schumacher, B., Pecher, P., Von Specht, B.U. & Induction of neoan-giogenesis in ischemic myocardium by human growth factors. Circulation 97, 645–650(1998).

    Article  CAS  Google Scholar 

  13. Suri, C., et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171–1180 (1996).

    Article  CAS  Google Scholar 

  14. Giordano, F.J. et al. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nature Med. 2, 534–539 (1996).

    Article  CAS  Google Scholar 

  15. Muhlhauser, J. et al. Safety and efficacy of in vivo gene transfer into the porcine heart with replication-deficient recombinant adenovirus vectors. Gene Ther. 3, 145–153(1996).

  16. Baumgartner, I. et al. Constitutive expression of phVEGFl 65 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 97, 1114–1123 (1998).

    Article  CAS  Google Scholar 

  17. Campbell, A.I.M., Monge, J.C., Latter, M.A., Kuliszewski, M.A. & Stewart, D.J. Direct DNA injection of vascular endothelial growth factor induces angiogenesis in non-ischemic myocardium. J. Am. Coll. Card. 31, 25A (1998).

    Article  Google Scholar 

  18. Isner, J.M. et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348, 370–374 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joon S. Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, J., Feldman, A. Gene therapy for therapeutic myocardial angiogenesis: A promising synthesis of two emerging technologies. Nat Med 4, 739–742 (1998). https://doi.org/10.1038/nm0698-739

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0698-739

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing