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Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase

Nature Medicine volume 3, pages 665–670 (1997)Cite this article

Abstract

Chimpanzees were challenged with HIV-1IIIB while receiving a short regimen of nevirapine (Viramune), a nonnucleoside inhibitor of HIV-1 reverse transcriptase. The untreated, control chimpanzee developed an infection characterized by seroconversion, viremia in peripheral blood mononuclear cells (PBMCs), and plasma positive for viral RNA. In contrast, the three nevirapine-treated chimpanzees remained negative for all viral markers with the exception of nested polymerase chain reaction (PCR) analysis of PBMCs for viral DNA. Although PBMCs from the three nevirapine-treated chimpanzees tested intermittently positive for viral DNA, this PCR signal disappeared and remained negative for the final five months of the study. These data indicate that orally administered nevirapine provided protection from HIV-1 infection in the chimpanzee model.

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Authors and Affiliations

  1. Department of Inflammatory Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut, 06877, USA

    Peter M. Grob & Cheng-Kon Shih

  2. Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, New York, New York, 10016, USA

    Yunzhen Cao & David D. Ho

  3. Laboratory for Experimental Medicine and Surgery in Primates, Tuxedo, New York, 10987, USA

    Elizabeth Muchmore

  4. Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut, 06877, USA

    Steve Norris & Joseph W. Pav

  5. ProScript Inc., 38 Sidney Street, Cambridge, Massachusetts, 02139, USA

    Julian Adams

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Grob, P., Cao, Y., Muchmore, E. et al. Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase. Nat Med 3, 665–670 (1997). https://doi.org/10.1038/nm0697-665

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