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A CUE hints at tumor resistance

Nature Medicine volume 17, pages 658–660 (2011)Cite this article

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Some individuals with estrogen receptor–α (ER-α)-positive breast cancer do not respond to tamoxifen treatment. Increased expression of the ubiquitin ligase CUEDC2 may contribute to this endocrine resistance by reducing theamounts of ER-α (pages 708–714).

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Figure 1: CUEDC2 and ER-α expression in tamoxifen-resistant tumor cells.

Renee Lucas

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Authors and Affiliations

  1. Department of Biology and Biochemistry, Christoforos Thomas and Jan-Ake Gustafsson are at the Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA,

    Christoforos Thomas & Jan-Ake Gustafsson

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  1. Christoforos Thomas
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  2. Jan-Ake Gustafsson
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Correspondence to Jan-Ake Gustafsson.

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Thomas, C., Gustafsson, JA. A CUE hints at tumor resistance. Nat Med 17, 658–660 (2011). https://doi.org/10.1038/nm0611-658

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