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Cross-dressing T cells go wild

Massive numbers of T cells infiltrate the epithelial cells of the intestine in people with celiac disease, caused by hypersensitivity to gluten. New findings show how some of these T cells become dangerous by taking on the characteristics of natural killer cells.

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Figure 1: T cells can be reprogrammed to become NK-like cells and express fully activating NK receptors in chronic inflammation.

Ann Thomson

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Sollid, L., Vaage, J. Cross-dressing T cells go wild. Nat Med 12, 611–612 (2006). https://doi.org/10.1038/nm0606-611

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