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Getting balance: Drugs for bipolar disorder share target

Nature Medicine volume 8, pages 557–558 (2002)Cite this article

Lithium and anticonvulsants such as valproic acid have the same end result: a more stable life for people with bipolar disorder. Now it seems they may also affect the same biochemical pathway in the brain.

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Figure 1: Intracellular signaling cascades involved in long term stabilization of mood by lithium (Li) and valproic acid (VPA).

Kimberly Homer

References

  1. Williams, R.S.B, Cheng, L., Mudge, A.W., Harwood, A.J. A common mechanism of action for three mood-stabilizing drugs. Nature, 417 292–295 (2002).

    Article  CAS  Google Scholar 

  2. Berridge, M.J., Downes, C.P. & Hanley, M.R. Neural and developmental actions of lithium: A unifying hypothesis. Cell. 59, 411–419 (1989).

    Article  CAS  Google Scholar 

  3. Manji, H.K. & Chen, G. PKC, MAP kinases and the bcl-2 family of proteins as long term targets for mood stabilizers. Mol. Psychiatry 7, S46–56 (2002).

    Article  CAS  Google Scholar 

  4. Lenox, R.H. & Hahn, C.G. Overview of the mechanism of action of lithium in the brain: Fifty-year update. J. Clin. Psychiatry. 61 (Suppl. 9), 5–15 (2000).

    CAS  PubMed  Google Scholar 

  5. Niculescu, A.B. 3rd & Kelsoe, J.R. Convergent functional genomics: Application to bipolar disorder. Ann Med. 33, 263–271 (2001).

    Article  CAS  Google Scholar 

  6. Klein, P.S. & Melton, D.A. A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. USA 93, 8455–8459 (1996).

    Article  CAS  Google Scholar 

  7. Maes, M. et al. Alterations in plasma prolyl endopeptidase activity in depression, mania and schizophrenia; effects of antidepressants, mood stabilizers and antipsychotic drugs. Psychiatry Res. 58, 217–225 (1995).

    Article  CAS  Google Scholar 

  8. Duman, R.S. Synaptic plasticity and mood disorders. Mol. Psychiatry 7, 29–34 (2002).

    Article  Google Scholar 

  9. Drevets, W.C. Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr. Opin. Neurobiol. 11, 240–249 (2001).

    Article  CAS  Google Scholar 

  10. Chen, G., Einat, H., Yuan, P. & Manji, H.K. Evidence for the involvement of the MAP/ERK signaling cascade in mood modulation. Biol. Psychiatry (in the press).

  11. Tsai, G. & Coyle, J.T. N-acetylaspartate in neuropsychiatric disorders. Prog. Neurobiol. 46, 531–540 (1995).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. McLean Department of Psychiatry Harvard Medical School, Belmont, Massachusetts, USA

    Joseph T. Coyle

  2. National Institute of Mental Health, Bethesda, Maryland, USA

    Husseini K. Manji

Authors
  1. Joseph T. Coyle
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  2. Husseini K. Manji
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Coyle, J., Manji, H. Getting balance: Drugs for bipolar disorder share target. Nat Med 8, 557–558 (2002). https://doi.org/10.1038/nm0602-557

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