Heme oxygenase-1, an enzyme expressed during injury, reduces vasoconstriction and inhibits formation of free radicals. Someday it might be used as a local therapeutic agent at sites of vascular injury (Pages 693–698).
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References
Duckers, H.R. Heme oxygenase-1 protects against vascular constriction and proliferation. Nature Med. 7, 692–698 (2001).
Glass, C.K. & Witztum, J.L. Atherosclerosis-the road ahead. Cell 104, 503–516 (2001).
Cai, H. & Harrison, D. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ. Res. 87, 840–844 (2000).
Shimokawa, H. Cellular and molecular mechanisms of coronary artery spasm: Lessons from animal models. Jpn. Circ. J. 64, 1–12 (2000).
Togane, Y. et al. Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury. Am. J. Physiol. Heart Circ. Physiol. 278, H623–H632 (2000).
Ishikawa, K. et al. Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circ. Res. 88, 506–512 (2001).
Schultz, D. & Harrison, D.G. Quest for fire: Seeking the source of pathogenic oxygen radicals in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20, 1529–1535 (2000).
McCall, M.R. & Frei, B. Can antioxidant vitamins materially reduce oxidative damage in humans? Free. Radic. Biol. Med. 26, 1034–1053 (1999).
Toyoda, K., Andresen, J.J., Zabner, J., Faraci, F.M. & Heistad, D.D. Calcium phosphate precipitates augment adenovirus-mediated gene transfer to blood vessels in vitro and in vivo. Gene Ther. 7, 1284–1291 (2000).
Bennett, M.R. Reactive oxygen species and death: oxidative DNA damage in atherosclerosis. Circ. Res. 88, 648–650 (2001).
Schneider, D.B. et al. Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation. Arterioscler. Thromb. Vasc. Biol. 20, 298–308 (2000).
Schulick, A.H. et al. Overexpression of transforming growth factor beta1 in arterial endothelium causes hyperplasia, apoptosis and cartilaginous metaplasia. Proc. Natl. Acad. Sci. USA 95, 6983–6988 (1998).
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Schwartz, S. A protective player in the vascular response to injury. Nat Med 7, 656–657 (2001). https://doi.org/10.1038/89019
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DOI: https://doi.org/10.1038/89019