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Cleaning up on β-catenin

Inactivation of the APC tumor suppressor gene in melanoma and colon cancer results in increased transcriptional activity mediated by β-catenin.

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References

  1. Kinzler, K.W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159–170 (1996).

    Article  CAS  Google Scholar 

  2. Korinek, V. et al. Constitutive transcriptional activation by a β-catenin–Tcf complex in APC-/-colon carcinoma. Science 275, 1784–1787 (1997).

    Article  CAS  Google Scholar 

  3. Morin, P.J. et al. Activation of β-catenin–Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275, 1787–1790 (1997).

    Article  CAS  Google Scholar 

  4. Rubinfeld, B. et al. Stabilization of β-catenin by genetic defects in melanoma Cell lines. Science 275, 1790–1792 (1997).

    Article  CAS  Google Scholar 

  5. Behrens, J. et al. Functional interaction of b-catenin with the transcription factor LEF-1. Nature 382, 638–642 (1996).

    Article  CAS  Google Scholar 

  6. Molenaar, M. et al, Xtcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell 86, 391–399 (1996).

    Article  CAS  Google Scholar 

  7. Takeda, H. et al. V-src kinase shifts the cadherin-based Cell adhesion from the strong to weak state and β-catenin is not required for the shift. J. Cell Biol. 131, 1839–1847 (1995).

    Article  CAS  Google Scholar 

  8. Hoschuetzky, H., Aberle, H. & Kemler, R. β-Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol. 127, 1375–1380 (1994).

    Article  CAS  Google Scholar 

  9. Shibata, T. et al. Dominant negative inhibition of the association between β-catenin and c-erbB-2 by N-terminally deleted β-catenin suppresses the invasion and metastasis of cancer Cells. Oncogene 13, 883–889 (1996).

    CAS  PubMed  Google Scholar 

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Nakamura, Y. Cleaning up on β-catenin. Nat Med 3, 499–500 (1997). https://doi.org/10.1038/nm0597-499

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