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Cellular proofreading

Evidence accumulates that cells, like DMA polymerases, can erase their mistakes (pages 577–580).

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References

  1. Nicol, C.J., Harrison, M.L., Laposa, R.R., Gimelshtein, I.L. & Wells, P.O. A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. Nature Genet 10, 181–187 (1995).

    Article  CAS  Google Scholar 

  2. Armstrong, J.F., Kaufman, M.H., Harrison, D.J. & Clarke, A.R. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol 5, 931–936 (1995).

    Article  CAS  Google Scholar 

  3. Norimura, T., Nomoto, S., Katsuki, M., Gondo, Y. & Kondo, S. p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nature Med. 2, 577–580 (1996).

    Article  CAS  Google Scholar 

  4. White, E. p53, guardian of Rb. Nature 371, 21–22 (1994).

    Article  CAS  Google Scholar 

  5. Ziegler, A. et al. Sunburn and p53 in the onset of skin cancer. Nature 372, 773–776 (1994).

    Article  CAS  Google Scholar 

  6. Allan, D.J., Harmon, B.V. & Kerr, J.F.R. Cell death in spermatogenesis. in Perspectives on Mammalian Cell Death (ed. Potten, C.S.) 229–258 (Oxford University Press, Oxford, 1987).

    Google Scholar 

  7. Russell, W.L. Genetic effects of radiation in mammals, in Radiation Biology Vol. I: High Energy Radiation; Part II (ed. Hollaender, A.) 825–859 (McGraw-Hill, New York, 1954).

    Google Scholar 

  8. Russell, L.B. & Saylors, C.L. The relative sensitivity of various germ-cell stages of the mouse to radiation-induced nondisjunction, chromosome losses and deficiencies. in Repair from Genetic Radiation Damage (ed. Sobels, F.H.) 313–349 (Macmillan, New York, 1963).

    Google Scholar 

  9. Matsuda, Y., Hirobe, T. & Chapman, V.M. Genetic basis of X-Y chromosome dissociation and male sterility in interspecific hybrids. Proc. Natl. Acad. Sci. USA 88, 4850–4854 (1991).

    Article  CAS  Google Scholar 

  10. Sutcliffe, M.J., Darling, S.M. & Burgoyne, P.S. Spermatogenesis in XY, XYSxra and XOSxra mice: A quantitative analysis of spermatogenesis throughout puberty. Mol. Reprod. Dev. 30, 81–89 (1991).

    Article  CAS  Google Scholar 

  11. Coucouvanis, E.G., Sherwood, S.W., Carswell-Crumpton, C., Spack, E.G. & Jones, P.P. Evidence that the mechanism of prenatal germ cell death in the mouse is apoptosis. Exp. Cell Res. 209, 238–247 (1993).

    Article  CAS  Google Scholar 

  12. Rotter, V. et al. Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. Proc. Natl. Acad. Sci. USA 90, 9075–9079 (1993).

    Article  CAS  Google Scholar 

  13. Miklos, G.L.G. Sex-chromosome pairing and male fertility. Cytogenet. Cell Genet. 13, 558–577 (1974).

    Article  CAS  Google Scholar 

  14. Burgoyne, P.S., Mahadevaiah, S.K., Sutcliffe, M.J. & Palmer, S.J. Fertility in mice requires X-Y pairing and a Y-chromosomal “spermiogenesis” gene mapping to the long arm. Cell 71, 391–398 (1992).

    Article  CAS  Google Scholar 

  15. Buss, L.W. The Evolution of Individuality, p. 201 (Princeton University Press, Princeton, 1987).

    Google Scholar 

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Brash, D. Cellular proofreading. Nat Med 2, 525–526 (1996). https://doi.org/10.1038/nm0596-525

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  • DOI: https://doi.org/10.1038/nm0596-525

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