Thiazolidinediones (TZDs) target peroxisome proliferator–activated receptor-γ (PPAR-γ) and are widely prescribed to treat type 2 diabetes but are associated with substantial weight gain. This side effect of TZDs is now shown to be mediated via brain PPAR-γ. These findings suggest an important role for brain PPAR-γ in obesity and have major implications for the clinical use of TZDs (pages 618–622 and 623–626).
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Myers, M., Burant, C. PPAR-γ action: it's all in your head. Nat Med 17, 544–545 (2011). https://doi.org/10.1038/nm0511-544
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DOI: https://doi.org/10.1038/nm0511-544
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