Fat cells secrete the hormone adiponectin, which regulates glucose metabolism through actions on peripheral tissues. It is now apparent that adiponectin also acts on the brain to reduce body weight and improve glucose metabolism (pages 524–529).
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Seeley, R., D'Alessio, D. & Woods, S. Fat hormones pull their weight in the CNS. Nat Med 10, 454–455 (2004). https://doi.org/10.1038/nm0504-454
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DOI: https://doi.org/10.1038/nm0504-454
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