Neurodenerative disorders such as Huntington disease lead to neuronal cell death in discrete regions of brain. A new study implicates the CREB transcription factor family as critical mediators that prevent such neuronal death.
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References
Mantamadiotis, T. et al. Disruption of CREB function in brain leads to neurodegeneration. Nature Genet. 31, 47–54 (2002).
Mayr, B. & Montminy, M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nature Rev. Mol. Cell. Biol. 2, 599–609 (2001).
Bonni, A. et al. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358–1362 (1999).
Riccio, A., Ahn, S., Davenport, C.M., Blendy, J.A. & Ginty, D.D. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286, 2358–2361 (1999).
Lonze, B.E., Riccio, A., Cohen, S. & Ginty, D.D. Apoptosis, axonal growth defects and degeneration of peripheral neurons in mice lacking CREB. Neuron (in the press).
McCampbell, A. et al. CREB-binding protein sequestration by expanded polyglutamine. Hum. Mol. Genet. 9, 2197–2202 (2000).
Steffan, J.S. et al. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc. Natl. Acad. Sci. USA 97, 6763–6768 (2000).
Steffan, J.S. et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413, 739–743 (2001).
Nucifora, F.C., et al. Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity. Science 291, 2423–2428 (2001).
Shimohata, T. et al. Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. Nature Genet. 26, 29–36 (2000).
McCampbell, A. et al. Histone deacetylase inhibitors reduce polyglutamine toxicity. Proc. Natl. Acad. Sci. USA 98, 15179–15184 (2001).
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Dawson, T., Ginty, D. CREB family transcription factors inhibit neuronal suicide. Nat Med 8, 450–451 (2002). https://doi.org/10.1038/nm0502-450
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DOI: https://doi.org/10.1038/nm0502-450
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