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Orexins and appetite: The big picture of energy homeostasis gets a little bigger

Nature Medicine volume 4, pages 385–386 (1998)Cite this article

The discovery of orexins adds to a rapidly evolving picture of how food intake and body fat are regulated.

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References

  1. Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G-protein-coupled receptors that regulate feeding behavior. Cell 92, 573–585 (1998).

    Article  CAS  Google Scholar 

  2. Schwartz, M. & Seeley, R. Neuroendocrine responses to starvation and weight loss. New Engl. J. Med. 336, 1802–1811 (1997).

    Article  CAS  Google Scholar 

  3. Stephens, T.W. et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530–532 (1995).

    Article  CAS  Google Scholar 

  4. Schwartz, M.W. et al. Leptin increases proopiome-lanocortin (POMC) mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119–2123 (1997).

    Article  CAS  Google Scholar 

  5. Cone, R. et al. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Progress In Hormone Research 51, 287–318 (1996).

    CAS  PubMed  Google Scholar 

  6. Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131–141 (1997).

    Article  CAS  Google Scholar 

  7. Ollmann, M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135–138 (1997).

    Article  CAS  Google Scholar 

  8. Seeley, R. et al. Evidence that the hypothalamic melanocortin system mediates leptin's effects on food intake and body weight. Nature 390, 349 (1997).

    Article  CAS  Google Scholar 

  9. Stanley, B.G., Kyrkouli, S.E., Lampert, S. & Leibowitz, S.F. Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity. Peptides 7, 1189–1192 (1986).

    Article  CAS  Google Scholar 

  10. Rossi, M. et al. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138, 351–155 (1997).

    Article  CAS  Google Scholar 

  11. Smith, B., York, D. & Bray, G. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity. Peptides 15, 1267–1272 (1994).

    Article  CAS  Google Scholar 

  12. Schaffhauser, A.O. et al. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynu-cleotides. Diabetes 46, 1792–1798 (1997).

    Article  CAS  Google Scholar 

  13. Erickson, J.C., Clegg, K.E. & Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415–418 (1996).

    Article  CAS  Google Scholar 

  14. Connolly, H. et al. Valvular heart disease associated with fenfluramine-phentermine. New Engl. J. Med. 337, 581–588 (1997).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, Washington, 98108, USA

    Michael W. Schwartz

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  1. Michael W. Schwartz
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Schwartz, M. Orexins and appetite: The big picture of energy homeostasis gets a little bigger. Nat Med 4, 385–386 (1998). https://doi.org/10.1038/nm0498-385

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