Adenoviral transfer of NT-3 and CNTF genes provides therapeutic benefit to mice with motor neuron disease (pages 429–436).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Appel, S.H. A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease. Ann. Neurol. 10, 499–505 (1981).
Dittrich, F., Thoenen, H. & Sendtner, M. Ciliary neurotrophic factor: Pharmacokinetics and acute phase response. Ann. Neurol. 35, 151–163 (1994).
Eriksson, N.P., Lindsay, R.M. & Aldskogius, H. BDNF and NT-3 rescue sensory but not motoneurones following axotomy in the neonate. Neuroreport 5, 1445–1448 (1994).
Vejsada, R., Sagot, Y. & Kato, A.C. Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo. Eur. J. Neurosci. 7, 108–115 (1995).
Carter, B.D., Zirrgiebel, U. & Barde, Y.-A. Differential regulation of p21ras activation in neurons by nerve growth factor and brain-derived neurotrophtc factor. J. Biol. Chem. 270, 21751–21757 (1995).
Haase, G. et al. Gene therapy of a murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nature Med. 3, 429–436 (1997).
Dittrich, F. et al. Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons. Exp. Neurol. 141, 225–239 (1996).
Yan, Q. et al. Influences of neurotrophins on mammalian motoneurons in vivo. J. Neurobiol. 24, 1555–1577 (1993).
Henderson, C.E. et al. Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363, 266–270 (1993).
Griesbeck, O. et al. Expression of neurotrophins in skeletal muscle: Quantitative comparison and significance for motoneuron survival and maintenance of function. J. Neurosci. Res. 42, 21–33 (1995).
Lohof, A.M., Ip, N.Y. & Poo, M. Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 363, 350–353 (1993).
Sagot, Y., Tan, S.A., Hammang, J.P., Aebischer, P. & Kato, A.C. GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice. J. Neurosci. 16, 2335–2341 (1996).
Sendtner, M. et al. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358, 502–504 (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sendtner, M. Gene therapy for motor neuron disease. Nat Med 3, 380–381 (1997). https://doi.org/10.1038/nm0497-380
Issue Date:
DOI: https://doi.org/10.1038/nm0497-380
This article is cited by
-
Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway
Nature Cell Biology (2000)
-
Neuron-restrictive silencer elements mediate neuron specificity of adenoviral gene expression
Nature Biotechnology (1999)