Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Tumor suppressor genes in the TGF–β signaling pathway?

Loss of response to TGF-βs may be an important step in the development and progression of cancer. Recent studies show that receptors and proteins involved in TGF-β signaling may act as tumor suppressors.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Tucker, R.F., Shipley, G.D., Moses, H.L. & Holley, R.W. Growth inhibitor from BSC-1 cells closely related to the platelet type beta transforming growth factor. Science 226, 705–707 (1984).

    Article  CAS  PubMed  Google Scholar 

  2. Pierce, D.F. Jr., et al. Mammary tumor suppression by transforming growth factor β1 transgene expression. Proc. Natl. Acad. Sci. USA 92, 4254–4258 (1995).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Blessing, M., Nanney, L.B., King, L.E. & Hogan, B.L.M. Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-β related transgene. Teratogen. Carcinogen. Mutagen. 15, 11–21 (1995).

    Article  CAS  Google Scholar 

  4. Massagué, J., Attisano, L. & Wrana, J.L., TGF-β family and its composite receptors. Trends Cell Biol. 4, 172–178 (1994).

    Article  PubMed  Google Scholar 

  5. Markowitz, S. et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268, 1336–1338 (1995).

    Article  CAS  PubMed  Google Scholar 

  6. Chen, R.H., Miettinen, P.J., Maruoka, E.M., Choy, L. & Derynck, R. A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor. Nature 377, 548–552 (1995).

    Article  CAS  PubMed  Google Scholar 

  7. Kawabata, M., Imamura, T., Miyazono, K., Engel, M.E. & Moses, H.L. Interaction of the transforming growth factor-β type I receptor with farnesylprotein transferase-α. J. Biol. Chem. 270, 29628–29631 (1995).

    Article  CAS  PubMed  Google Scholar 

  8. Wang, T., Donahoe, P.K. & Zervos, A.S. Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP-12. Science 265, 674–676 (1994).

    Article  CAS  PubMed  Google Scholar 

  9. Alexandrow, M.G. & Moses, H.L. Transforming growth factor β and cell cycle regulation. Cancer Res. 55, 1452–1457 (1995).

    CAS  PubMed  Google Scholar 

  10. Hannon, G.J. & Beach, D. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371, 257–261 (1994).

    Article  CAS  PubMed  Google Scholar 

  11. Hahn, S.A. et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350–353 (1996).

    Article  CAS  PubMed  Google Scholar 

  12. Sekelsky, J.J., Newfeld, S.J., Raftery, L.A., Chartoff, E.H. & Gelbart, W.M. Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 1347–1358 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Ruberte, E., Marty, T., Nellen, D., Affolter, M. & Basler, K. An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo. Cell 80, 889–897 (1995).

    Article  CAS  PubMed  Google Scholar 

  14. Savage, C. et al. Caenorhabditis elegans genes sma2, sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components. Proc. Natl. Acad. Sci. USA 93, 790–794 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Goyette, M.C. et al. Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol. Cell. Biol. 12, 1387–1395 (1992).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Serra, R., Moses, H. Tumor suppressor genes in the TGF–β signaling pathway?. Nat Med 2, 390–391 (1996). https://doi.org/10.1038/nm0496-390

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0496-390

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing