By the time diabetes is diagnosed, irreversible pathology is typically present, challenging therapeutic intervention. A reliable test for predicting diabetes risk could allow earlier implementation of intervention measures. Increased blood concentrations of amino acids are now suggested to predict risk of diabetes (pages 448–453), and amino acid profiling might also provide mechanistic insights into this disease.
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References
Randle, P.J., Garland, P.B., Hales, C.N. & Newsholme, E.A. Lancet 1, 785–789 (1963).
Muoio, D.M. & Newgard, C.B. Nat. Rev. Mol. Cell Biol. 9, 193–205 (2008).
Felig, P., Marliss, E. & Cahill, G.F. Jr. N. Engl. J. Med. 281, 811–816 (1969).
Newgard, C.B. et al. Cell Metab. 9, 311–326 (2009).
Tai, E.S. et al. Diabetologia 53, 757–767 (2010).
Pietiläinen, K.H. et al. PLoS Med. 5, e51 (2008).
Wang, T.J. et al. Nat. Med. 17, 448–453 (2011).
Lyssenko, V. et al. N. Engl. J. Med. 359, 2220–2232 (2008).
Salomaa, V. et al. PLoS ONE 5, e10100 (2010).
Cook, N.R. Clin. Chem. 54, 17–23 (2008).
Hardie, D.G. Nat. Rev. Mol. Cell Biol. 8, 774–785 (2007).
Howell, J.J. & Manning, B.D. Trends Endocrinol. Metab. 22, 94–102 (2011).
Tremblay, F. et al. Proc. Natl. Acad. Sci. USA 104, 14056–14061 (2007).
Herman, M.A., She, P., Peroni, O.D., Lynch, C.J. & Kahn, B.B. J. Biol. Chem. 285, 11348–11356 (2010).
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Langenberg, C., Savage, D. An amino acid profile to predict diabetes?. Nat Med 17, 418–420 (2011). https://doi.org/10.1038/nm0411-418
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DOI: https://doi.org/10.1038/nm0411-418
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