Immunotherapy for allergies can be an imperfect and unpredictable exercise; immunization with allergens can even lead to an acute allergic response. A new approach, involving fusing the allergen to a protein that modulates the immune response, could provide a more effective and safer alternative (pages 446–449).
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References
Galli, S. J. et al. Annu. Rev. Immunol. 23, 749–786 (2005).
Marone, G., Triggiani, M. & de Paulis, A. Trends Immunol. 26, 25–31 (2005).
Malbec, O., Fridman, W. H. & Daeron, M. Curr. Top. Microbiol. Immunol. 244, 13–27 (1999).
MacGlashan, D. W., Jr. et al. J. Immunol. 158, 1438–1445 (1997).
Takai, T., Ono, M., Hikida, M., Ohmori, H. & Ravetch, J.V. Nature 379, 346–349 (1996).
Zhu, D., Kepley, C.L., Zhang, M., Zhang, K. & Saxon, A. Nat. Med. 8, 518–521 (2002).
Zhu, D. et al. Nat. Med. 11, 446–449 (2005).
Golden, D. J. Allergy Clin. Immunol. 115, 439–447 (2005).
Holgate, S. et al. J. Allergy Clin. Immunol. 115, 459–465 (2005).
Leung, D. Y. et al. N. Engl. J. Med. 348, 986–993 (2003).
Kay, A. B. Ciba Found. Symp. 206, 56–70 (1997).
Williams, C. M. & Galli, S. J. J. Allergy Clin. Immunol. 105, 847–859 (2000).
Metzger, H. et al. Annu. Rev. Immunol. 4, 419–470 (1986).
Turner, H. & Kinet, J. P. Nature 402, B24–B30 (1999).
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Kalesnikoff, J., Galli, S. Nipping cat allergy with fusion proteins. Nat Med 11, 381–382 (2005). https://doi.org/10.1038/nm0405-381
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DOI: https://doi.org/10.1038/nm0405-381
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