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Block the FAS, lose the fat

A small-molecular-weight drug originally developed to treat cancer produces sustained reduction in body weight in obese mice by a novel hypothalamic mechanism. The findings suggest new targets for the development of anti-obesity drugs.

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Figure 1: Model of how nutrients and hormones converge on the pathway mediating effects of FAS inhibitors on body weight.

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Mobbs, C., Makimura, H. Block the FAS, lose the fat. Nat Med 8, 335–336 (2002). https://doi.org/10.1038/nm0402-335

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