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De-mystifying the mechanism(s) of maspin

Nature Medicine volume 6, pages 374–376 (2000)Cite this article

Recent findings indicate that p53 regulates the expression of the tumor suppressor gene maspin, providing new mechanistic information about the factors that negatively regulate tumor cell metastasis.

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Figure 1: Hypothetical model for the expression of maspin (mammary serine protease inhibitor) in a normal mammary epithelial cell, in which the tumor suppressive function of maspin is intact along with transactivation through the (Ets) element.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology The University of Iowa College of Medicine Bowen Science Building and University of Iowa Cancer Center, Iowa City, 52242-1109, Iowa, USA

    Mary J.C. Hendrix

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  1. Mary J.C. Hendrix
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Hendrix, M. De-mystifying the mechanism(s) of maspin. Nat Med 6, 374–376 (2000). https://doi.org/10.1038/74624

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