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Getting to the core of the matter

Engineering chylomicron vesicles to target drugs to the liver may provide effective new treatments for hepatitis B and other liver diseases (pages 221–225).

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References

  1. Ashwell, G. & Morell, A.D. The role of surface carbohydrates in the hepatic recognition and transport of circulation glycoproteins. Adv. Enzymol. 4, 99–128 (1974).

    Google Scholar 

  2. Huber, B.E. Late stage spermatids are characterized by expression of the ‘Liver-Specific’ asialoglycoprotein receptor. RHL-1 Molec. Pharmacol. 41, 639–644 (1992).

    CAS  Google Scholar 

  3. Mu, J.Z. et al. Asialoglycoprotein receptor mRNAs are expressed in most extraheptaic rat tissues during development. Am. J. Physiol. 264, G752–G762 (1993).

    CAS  PubMed  Google Scholar 

  4. Fiume, L. et al. Enhanced inhibition of virus DNA synthesis in hepatocytes by trifluorothymidine coupled to asialofetuin. FEBS Lett. 103, 47–51 (1979).

    Article  CAS  Google Scholar 

  5. Fiume, L. et al. Selective inhibition of Ectromelia virus DNA synthesis in hepatocytes by ara-A and ara-AMP conjugated to asialofetuin. FEBS Lett. 116, 185–188 (1980).

    Article  CAS  Google Scholar 

  6. Torrani Cerenzia, M.R. et al. Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy, minimal effective dose and plasma clearance of conjugate. J. Hepatol. 20 (2), 307–309 (1994).

    Article  CAS  Google Scholar 

  7. Wu, G.Y. et al. Model for specific rescue of normal hepatocytes during methotrexate treatment of hepatic malignancy. Proc. natn. Acad. Sci. U.S.A. 80, 3078–3080 (1983).

    Article  CAS  Google Scholar 

  8. Wu, G.Y. et al. Acetaminophen hepatoxicity and targeted rescue: A model for specific chemotherapy of hepatocellular carcinoma. Hepatology 5, 709–713 (1985).

    Article  CAS  Google Scholar 

  9. Bijsterbosch, M.K. et al. Lactosylated low-density lipoprotein: A potential carrier for the site-specific delivery of drugs to Kupffer cells. Molec. Pharmacol. 36, 484–489 (1989).

    CAS  Google Scholar 

  10. Mommaas-Kienhuis, A.M. et al. Visualization of the interaction of native and modified low-density lipoproteins with isolated rat liver cells. Eur. J. Cell Biol. 38, 42–50 (1985).

    CAS  PubMed  Google Scholar 

  11. Van der Sluijs, P., Bootsma, H.P., Postema, B., Moolenaar, F. & Meijer, D.F.K. Drug targeting to the liver with the lactosylated albumins. Does the glycoprotein target the drug, or is the drug targeting the glycoprotein?. Hepatology 6, 723–728 (1990).

    Article  Google Scholar 

  12. Floren, C.H. & Nilsson, A. Binding, interiorization and degradation of cholesteryl ester-labelled chylomicron remnant particles by rat hepatocyte monolayers. Biochem. J. 168, 483–494 (1978).

    Article  Google Scholar 

  13. Gregoriadis, G. & Florence, A.T. Liposomes in drug delivery: Clinical, diagnostic and ophthalmic potential. Drugs 45, 15–28 (1993).

    Article  CAS  Google Scholar 

  14. Rensen, P.C.N., van Dijk, M.C.M., Havenaar, E.C., Bijsterbosch, M.K., Kruijt, J.K. & van Berkel, T.J.C. Nature Med. 1, 221–225 (1995).

    Article  CAS  Google Scholar 

Download references

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Hassan, N., Wu, G. Getting to the core of the matter. Nat Med 1, 210–211 (1995). https://doi.org/10.1038/nm0395-210

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